منابع مشابه
The role of microRNAs in cellular senescence and age-related conditions of cartilage and bone
BACKGROUND AND PURPOSE We reviewed the current state of research on microRNAs in age-related diseases in cartilage and bone. METHODS PubMed searches were conducted using separate terms to retrieve articles on (1) the role of microRNAs on aging and tissue degeneration, (2) specific microRNAs that influence cellular and organism senescence, (3) microRNAs in age-related musculoskeletal condition...
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micrornas participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of micrornas in the pathogenesis of asthma. a review of the english medical literatures was conducted by searching pubmed for studies concerning asthma and micrornas. the results of the present study indicate that micrornas play important roles in regulating asthma immune res...
متن کاملRoles of microRNAs in prenatal chondrogenesis, postnatal chondrogenesis and cartilage-related diseases
Cartilage has limited repair and regeneration capacity, thus damage of cartilage often results in its dysfunction and even chronic diseases like osteoarthritis (OA). Chondrogenesis induced by tissue-engineering methods is essential to treating cartilage-related diseases. MicroRNAs (miRNAs) are a class of small non-coding single-stranded RNAs which exert their biological effects by binding to th...
متن کاملMicroRNAs that target RGS5
Objective(s):An earlier meta-analysis on gene expression data derived from four microarray, two cDNA library, and one SAGE experiment had identified RGS5 as one of only ten non-housekeeping genes that were reported to be expressed in human trabecular meshwork (TM) cells by all studies. RGS5 encodes regulator of G-protein signaling-5. The TM tissue is the route of aqueous fluid outflow, and is r...
متن کاملDifferentially Expressed MicroRNAs in Chondrocytes from Distinct Regions of Developing Human Cartilage
There is compelling in vivo evidence from reports on human genetic mutations and transgenic mice that some microRNAs (miRNAs) play an important functional role in regulating skeletal development and growth. A number of published in vitro studies also point toward a role for miRNAs in controlling chondrocyte gene expression and differentiation. However, information on miRNAs that may regulate a ...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2013
ISSN: 0736-0266
DOI: 10.1002/jor.22397